Revolutionize Your Protein Quantification Approach

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Applications

PICO enables groundbreaking applications in the areas of:

Highly-sensitive protein biomarker detection
Signaling pathway activity analysis
Disruptive cancer research applications
Innovative assays for pharmaceutical research
Extracellular vesicle (EV) analysis

Performance

The PICO Products are based on an immunoassay concept that utilizes digital PCR (dPCR) technology for readout. This unique approach results in the following powerful features and benefits:

True absolute quantification of protein targets - no need for external reference
Multiplex and high-throughput analysis - detect up to 96 samples simultaneously
Small input sample requirement (down to 1 µL) - save on precious samples
Femtomolar sensitivity - detect the undetectable targets
Homogeneous, wash-free workflow - no loss of material

Upcoming events

Meet us in person and learn about the power of PICO at the following conferences:

Visit us at ISEV 2025 in Vienna (April 24-27) at booth B19

Use-cases

The PICO technology expands the advantages of digital PCR into the world of proteins. PICO aims to replace traditional and cumbersome technologies such as western blot, co-immunoprecipitation (coIP), ELISA, and allows the development of novel quantitative protein assays.

200-fold sensitivity gain
Measure absolute amounts of your protein
More convenient workflow
Only one instrument required
Read our application note

Small input material required
200-fold sensitivity gain
No target enrichment required
Wash-free workflow
Read our application note

Detect both EV membrane and cargo proteins
Count EV vesicles in your sample
Read our application note

Quantification of post-translational modifications
splitPICO workflow for simultaneus quantification of up to 12 targets

PICO - The Absolute Protein Assay

Actome, in collaboration with your preferred antibody supplier, provides everything required for a comprehensive analysis of your protein targets.

Sample volumes down to 1 µL
Measurement in the native environment
Use cells, tissue, or any liquid biological samples
Quantify proteins, protein interactions and post-translational modifications

Use your own monoclonal antibodies
Pre-labeled antibodies are also available

Products:

Further information

Labeling of antibodies with PICOglue Labels
Robust & highly efficient PICOglue labeling technology

Products:

Further information

Digital assay with femtomolar sensitivtiy
Wash-free workflow
Zero background

Products:

Further information

Compatible with QIAGEN's QIAcuity dPCR instrument
Multiplexing: analyze up to 4 different PICOglue Labels simultaneously

Further information

Online analysis software
Personal cloud-based workspace
Free registration

Further information

Absolute quantification of targets
Direct graphical output of data
Basic statistical evaluation

PICO Kits & Services

Say hi to PICO and say bye to western blot, coIP, and ELISA!

PICO Kits

The PICO Kits guide you through the entire PICO workflow from antibody labeling to running the PICO Assay on your dPCR device. The PICO Kits are your perfect choice for performing PICO Assays in your lab.

Buy the PICO Kits Ask for a quote Discover the PICO Kits

PICO Services

We offer a comprehensive range of services to help you utilize the PICO technology. The services range from antibody labeling and quality control to fully customised PICO Assay development. Reach out to us below to discuss your project!